Compound Detail
CHEMBL3613625
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL3613625 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AEEYORYVZURZQF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
387.5
MW (Da)
2.65
ALogP
4
HBA
1
HBD
69.7
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.37
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 CHEMBL2775 | IC50 | 5.37 | 5.37 | 4300.0 | 1 |
| Transient receptor potential cation channel subfamily V member 4 CHEMBL3119 | IC50 | 5.07 | 5.07 | 8530.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 | IC50 | = | 4300.0 | nM | 5.37 | Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as ... | 26235950 |
| Transient receptor potential cation channel subfamily V member 4 | IC50 | = | 8530.0 | nM | 5.07 | Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed a... | 26235950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26235950 | 10.1016/j.bmcl.2015.06.098 | Transient receptor potential cation channel subfamily V member 4 | 2 |
Data from ChEMBL 36 via Core Engine