Compound Detail
CHEMBL3613633
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Basic Information
| ChEMBL ID | CHEMBL3613633 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PHJSLRWVEGAQCS-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
372.4
MW (Da)
3.21
ALogP
3
HBA
1
HBD
66.5
PSA (Ų)
0.90
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 CHEMBL3119 | IC50 | 5.38 | 5.38 | 4220.0 | 1 |
| Transient receptor potential cation channel subfamily V member 4 CHEMBL2775 | IC50 | 5.24 | 5.24 | 5740.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 4 | IC50 | = | 4220.0 | nM | 5.38 | Antagonist activity at human TRPV4 receptor expressed in HEK293 cells assessed a... | 26235950 |
| Transient receptor potential cation channel subfamily V member 4 | IC50 | = | 5740.0 | nM | 5.24 | Antagonist activity at rat TRPV4 receptor expressed in HEK293 cells assessed as ... | 26235950 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26235950 | 10.1016/j.bmcl.2015.06.098 | Transient receptor potential cation channel subfamily V member 4 | 2 |
Data from ChEMBL 36 via Core Engine