Compound Detail
CHEMBL3618325
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Basic Information
| ChEMBL ID | CHEMBL3618325 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RROGKYWCMQVOCW-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
465.9
MW (Da)
3.68
ALogP
8
HBA
0
HBD
73.9
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL1075228 | Ki | 9.3 | 9.3 | 0.5 | 1 |
| Melanin-concentrating hormone receptor 1 CHEMBL344 | Ki | 9.15 | 9.15 | 0.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | Ki | = | 0.5 | nM | 9.3 | Displacement of [125I][Phe13,Tyr19]-MCH from rat MCHR1 by scintillation counting... | 26386604 |
| Melanin-concentrating hormone receptor 1 | Ki | = | 0.7 | nM | 9.15 | Displacement of [125I][Phe13,Tyr19]-MCH from human MCHR1 expressed in HEK293 cel... | 26386604 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26386604 | 10.1016/j.bmcl.2015.09.018 | Melanin-concentrating hormone receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine