Compound Detail
CHEMBL362150
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O=C(NCCCOc1cccc2ccc(NCc3ccc(-c4ccccc4Cl)o3)nc12)Nc1ccc2c(c1)OCO2
Basic Information
| ChEMBL ID | CHEMBL362150 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZUDMBVUMZJVRKQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
571.0
MW (Da)
7.08
ALogP
7
HBA
3
HBD
106.9
PSA (Ų)
0.15
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 7.3 | 6.405 | 50.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 50.0 | nM | 7.3 | Concentration required to inhibit binding of [125I]-MCH radioligand to human Mel... | 15341943 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 3110.0 | nM | 5.51 | Concentration required to inhibit 50% of melanin-concentrating hormone induced [... | 15341943 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15341943 | 10.1016/j.bmcl.2004.07.034 | Melanin-concentrating hormone receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine