Assay Detail
Binding
CHEMBL832324
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Concentration required to inhibit binding of [125I]-MCH radioligand to human Melanin-concentrating hormone receptor 1 in IMR-32 I3.4.2 cell membranes
38
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Melanin-concentrating hormone receptor 1 (CHEMBL344) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of 2-amino-8-alkoxy quinolines as MCHr1 antagonists. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.77 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL182261 | — | — | 1 | 9.40 |
| CHEMBL184417 | — | — | 1 | 9.05 |
| CHEMBL359995 | — | — | 1 | 9.00 |
| CHEMBL362768 | — | — | 1 | 9.00 |
| CHEMBL183032 | — | — | 1 | 9.00 |
| CHEMBL184243 | — | — | 1 | 8.70 |
| CHEMBL182575 | — | — | 1 | 8.70 |
| CHEMBL184581 | — | — | 1 | 8.52 |
| CHEMBL185271 | SNAP-7941 | — | 1 | 8.52 |
| CHEMBL184080 | — | — | 1 | 8.30 |
| CHEMBL363464 | — | — | 1 | 8.30 |
| CHEMBL363664 | — | — | 1 | 8.30 |
| CHEMBL364210 | — | — | 1 | 8.22 |
| CHEMBL184191 | — | — | 1 | 8.15 |
| CHEMBL187162 | — | — | 1 | 8.00 |
| CHEMBL361878 | — | — | 1 | 8.00 |
| CHEMBL187847 | — | — | 1 | 8.00 |
| CHEMBL360393 | — | — | 1 | 8.00 |
| CHEMBL363683 | — | — | 1 | 8.00 |
| CHEMBL183159 | — | — | 2 | 7.70 |
| CHEMBL184590 | — | — | 1 | 7.52 |
| CHEMBL188058 | — | — | 1 | 7.52 |
| CHEMBL184477 | — | — | 1 | 7.40 |
| CHEMBL184589 | — | — | 1 | 7.30 |
| CHEMBL362150 | — | — | 1 | 7.30 |
| CHEMBL361262 | — | — | 1 | 7.22 |
| CHEMBL187003 | — | — | 1 | 7.16 |
| CHEMBL185236 | — | — | 1 | 7.10 |
| CHEMBL365041 | — | — | 1 | 7.10 |
| CHEMBL178707 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL182261 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL184417 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL362768 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL183032 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL359995 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL184243 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL182575 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL185271 | SNAP-7941 | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL184581 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL363664 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL363464 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL184080 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL364210 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL184191 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL363683 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187162 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL360393 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL187847 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL361878 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL183159 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL184590 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL188058 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL184477 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL362150 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL183159 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL184589 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL361262 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL187003 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL365041 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL185236 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL178707 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL364377 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL184087 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL369116 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL364399 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL362309 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL363701 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL363220 | — | IC50 | = | 660.0 | nM | 6.18 |