Compound Detail
CHEMBL365041
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Basic Information
| ChEMBL ID | CHEMBL365041 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JTXVIXJQQCNCCQ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
271.4
MW (Da)
2.58
ALogP
4
HBA
2
HBD
60.2
PSA (Ų)
0.85
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 CHEMBL344 | IC50 | 7.1 | 6.72 | 80.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanin-concentrating hormone receptor 1 | IC50 | = | 80.0 | nM | 7.1 | Concentration required to inhibit binding of [125I]-MCH radioligand to human Mel... | 15341943 |
| Melanin-concentrating hormone receptor 1 | IC50 | = | 460.0 | nM | 6.34 | Concentration required to inhibit 50% of melanin-concentrating hormone induced [... | 15341943 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15341943 | 10.1016/j.bmcl.2004.07.034 | Melanin-concentrating hormone receptor 1 | 2 |
Data from ChEMBL 36 via Core Engine