Compound Detail
CHEMBL3623128
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Basic Information
| ChEMBL ID | CHEMBL3623128 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LGXMELXVRWYYDN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names
Molecular Properties
281.3
MW (Da)
2.72
ALogP
3
HBA
2
HBD
82.0
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.75
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 4 CHEMBL6166 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 40.0 | mL.min-1.kg-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 4 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of MAP4K4 (unknown origin) by Z'LYTE assay | 26288693 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26288693 | 10.1021/acsmedchemlett.5b00174 | Mitogen-activated protein kinase kinase kinase kinase 4 | 1 |
| 26288693 | 10.1021/acsmedchemlett.5b00174 | Liver microsome | 1 |
| 26288693 | 10.1021/acsmedchemlett.5b00174 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine