Assay Detail
Binding
CHEMBL3624922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MAP4K4 (unknown origin) by Z'LYTE assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 4 (CHEMBL6166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Based Design of GNE-495, a Potent and Selective MAP4K4 Inhibitor with Efficacy in Retinal Angiogenesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.87 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3623135 | — | — | 1 | 8.85 |
| CHEMBL3623139 | — | — | 1 | 8.80 |
| CHEMBL3623137 | — | — | 1 | 8.46 |
| CHEMBL3623136 | — | — | 1 | 8.43 |
| CHEMBL3623138 | — | — | 1 | 8.43 |
| CHEMBL3623134 | — | — | 1 | 7.82 |
| CHEMBL3623128 | — | — | 1 | 7.75 |
| CHEMBL3623133 | — | — | 1 | 7.50 |
| CHEMBL3623131 | — | — | 1 | 7.39 |
| CHEMBL3623129 | — | — | 1 | 7.34 |
| CHEMBL3262580 | — | — | 1 | 7.24 |
| CHEMBL3623132 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3623135 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL3623139 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3623137 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3623136 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3623138 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL3623134 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL3623128 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3623133 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3623131 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3623129 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3262580 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL3623132 | — | IC50 | = | 401.0 | nM | 6.40 |