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Compound Detail

CHEMBL3623131

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Nc1ncc(C(=O)NC2CC(O)C2)c2ccc(-c3cccc(F)c3)cc12

Basic Information

ChEMBL ID CHEMBL3623131
Phase Preclinical
Structure Type MOL
InChI Key UAFIOOSLWDLMRI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
1
PK Parameters
3
Publications
0
Known Names

Molecular Properties

351.4
MW (Da)
2.88
ALogP
4
HBA
3
HBD
88.2
PSA (Ų)
0.68
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H18FN3O2
MW 351.38
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -0.61

Activity Summary

IC50 1 meas. best 7.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Mitogen-activated protein kinase kinase kinase kinase 4
CHEMBL6166
IC50 7.39 7.39 41.0 1

Pharmacokinetic Data

Parameter Value Units Species
CL 14.9 mL.min-1.kg-1 Rattus norvegicus

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26288693 10.1021/acsmedchemlett.5b00174 Mitogen-activated protein kinase kinase kinase kinase 4 1
26288693 10.1021/acsmedchemlett.5b00174 Liver microsome 1
26288693 10.1021/acsmedchemlett.5b00174 Rattus norvegicus 1

Data from ChEMBL 36 via Core Engine