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Compound Detail

CHEMBL362948

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CN1C(=O)c2c(c3c4ccc(O[Si](C)(C)C(C)(C)C)cc4[nH]c3c3cc4ccccc4cc23)C1=O
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL362948
Phase Preclinical
Structure Type MOL
InChI Key KZQTYGHOWBIOJZ-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

480.6
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H28N2O3Si
MW 480.64

Activity Summary

IC50 2 meas. best 5.25

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
DU-145
CHEMBL613508
 IC50 5.25 5.25 5600.0 1
L1210
CHEMBL386
 IC50 5.0 5.0 10100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
DU-145 IC50 = 5600.0 nM 5.25 In vitro antiproliferative activity against human prostate cancer DU145 cells 15743184
L1210 IC50 = 10100.0 nM 5.0 In vitro antiproliferative activity against murine leukemia L1210 cells 15743184

Literature References

PubMed DOI Target Context # Activities
15743184 10.1021/jm049213f L1210 1
15743184 10.1021/jm049213f DU-145 1
15743184 10.1021/jm049213f HT-29 1

Data from ChEMBL 36 via Core Engine