Compound Detail
CHEMBL3633803
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Basic Information
| ChEMBL ID | CHEMBL3633803 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IXRIVTBXLYNJMB-GFCCVEGCSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
409.5
MW (Da)
2.36
ALogP
8
HBA
1
HBD
90.9
PSA (Ų)
0.56
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 9.3 | 9.3 | 0.5 | 1 |
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255163 | IC50 | 5.27 | 5.27 | 5400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 0.5 | nM | 9.3 | Inhibition of Wnt/beta-catenin signalling in Wnt3a stimulated HEK293 cells asses... | 38621327 |
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 5400.0 | nM | 5.27 | Inhibition of porcupine in human HEK293 cells assessed as reduction in Wnt secre... | 26522946 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26522946 | 10.1016/j.bmcl.2015.10.032 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
| 38621327 | 10.1016/j.ejmech.2024.116408 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine