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Compound Detail

CHEMBL3650523

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CC(C)N1CCC(Nc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN(CC5=C(c6ccc(Cl)cc6)CC(C)(C)CC5)CC4)cc3Oc3ccccc3Cl)cc2[N+](=O)[O-])CC1

Basic Information

ChEMBL ID CHEMBL3650523
Phase Preclinical
Structure Type MOL
InChI Key WWMRKVILIDOUEB-UHFFFAOYSA-N
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

890.0
MW (Da)
9.88
ALogP
10
HBA
2
HBD
137.4
PSA (Ų)
0.10
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C46H54Cl2N6O6S
MW 889.95
Aromatic Rings 4
Heavy Atoms 61
NP-Likeness -1.19

Activity Summary

Ki 4 meas. best 10.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Apoptosis regulator Bcl-2
CHEMBL4860
Ki 10.57 10.57 0.0 4

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine