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Compound Detail

CHEMBL365541

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Cc1ccc(-c2cc3[nH]c(=O)n(CCCN4CCN(c5ccccc5Cl)CC4)c(=O)c3[nH]2)cc1

Basic Information

ChEMBL ID CHEMBL365541
Phase Preclinical
Structure Type MOL
InChI Key LJPDJPUNQXXBAB-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

478.0
MW (Da)
3.86
ALogP
5
HBA
2
HBD
77.1
PSA (Ų)
0.44
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H28ClN5O2
MW 478.00
Aromatic Rings 4
Heavy Atoms 34
NP-Likeness -1.41

Activity Summary

Ki 1 meas. best 6.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-1
CHEMBL1907610
Ki 6.96 6.96 110.1 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15801833 10.1021/jm040870h Adrenergic receptor alpha-1 1
15801833 10.1021/jm040870h 5-hydroxytryptamine receptor 1A 1
15801833 10.1021/jm040870h D(1A) dopamine receptor 1
15801833 10.1021/jm040870h D(2) dopamine receptor 1
15801833 10.1021/jm040870h Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 1

Data from ChEMBL 36 via Core Engine