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Compound Detail

CHEMBL365669

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C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(CS(=O)(=O)c2ccccc2)c1

Basic Information

ChEMBL ID CHEMBL365669
Phase Preclinical
Structure Type MOL
InChI Key YIAUQEMHLVUETN-CLOONOSVSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

542.7
MW (Da)
3.73
ALogP
7
HBA
3
HBD
125.6
PSA (Ų)
0.25
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H30N2O6S2
MW 542.68
Aromatic Rings 4
Heavy Atoms 37
NP-Likeness -0.69

Activity Summary

EC50 1 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.0 7.0 100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15686912 10.1016/j.bmcl.2004.12.033 Beta-3 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-1 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-2 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Caco-2 1

Data from ChEMBL 36 via Core Engine