Assay Detail
Functional
CHEMBL834517
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Agonistic activity was assessed by measuring cAMP accumulation in CHO cells expressing human beta-3 adrenergic receptor
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tryptamine-based human beta3-adrenergic receptor agonists. Part 3: improved oral bioavailability via modification of the sulfonamide moiety.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 8.00 | 9.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181440 | — | — | 1 | 9.27 |
| CHEMBL182018 | — | — | 1 | 9.00 |
| CHEMBL425161 | — | — | 1 | 8.92 |
| CHEMBL183552 | — | — | 1 | 8.54 |
| CHEMBL182689 | — | — | 1 | 8.49 |
| CHEMBL360133 | — | — | 1 | 8.19 |
| CHEMBL181603 | — | — | 1 | 8.05 |
| CHEMBL181300 | — | — | 1 | 8.00 |
| CHEMBL362293 | — | — | 1 | 7.96 |
| CHEMBL182614 | — | — | 1 | 7.82 |
| CHEMBL181964 | — | — | 1 | 7.77 |
| CHEMBL184584 | — | — | 1 | 7.50 |
| CHEMBL182770 | — | — | 1 | 7.44 |
| CHEMBL361577 | — | — | 1 | 7.28 |
| CHEMBL365669 | — | — | 1 | 7.00 |
| CHEMBL182708 | — | — | 1 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181440 | — | EC50 | = | 0.54 | nM | 9.27 |
| CHEMBL182018 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL425161 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL183552 | — | EC50 | = | 2.9 | nM | 8.54 |
| CHEMBL182689 | — | EC50 | = | 3.2 | nM | 8.49 |
| CHEMBL360133 | — | EC50 | = | 6.5 | nM | 8.19 |
| CHEMBL181603 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL181300 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL362293 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL182614 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL181964 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL184584 | — | EC50 | = | 32.0 | nM | 7.50 |
| CHEMBL182770 | — | EC50 | = | 36.0 | nM | 7.44 |
| CHEMBL361577 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL365669 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL182708 | — | EC50 | = | 160.0 | nM | 6.80 |