Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL360133

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CC#CCNc1cccc([C@@H](O)CN[C@H](C)Cc2c[nH]c3c(OS(C)(=O)=O)cccc23)c1

Basic Information

ChEMBL ID CHEMBL360133
Phase Preclinical
Structure Type MOL
InChI Key DMKHFWAHKHDPTF-VGSWGCGISA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

455.6
MW (Da)
3.20
ALogP
6
HBA
4
HBD
103.5
PSA (Ų)
0.28
QED
0
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H29N3O4S
MW 455.58
Aromatic Rings 3
Heavy Atoms 32
NP-Likeness -0.39

Activity Summary

EC50 2 meas. best 8.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 8.19 8.19 6.5 1
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.75 7.75 18.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15686912 10.1016/j.bmcl.2004.12.033 Beta-3 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-1 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-2 adrenergic receptor 2

Data from ChEMBL 36 via Core Engine