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Compound Detail

CHEMBL182708

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C[C@H](Cc1c[nH]c2c(OS(C)(=O)=O)cccc12)NC[C@H](O)c1cccc(NC(=O)c2ccccc2)c1

Basic Information

ChEMBL ID CHEMBL182708
Phase Preclinical
Structure Type MOL
InChI Key WYTFAQBIDABWBM-KOSHJBKYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

507.6
MW (Da)
4.01
ALogP
6
HBA
4
HBD
120.5
PSA (Ų)
0.24
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H29N3O5S
MW 507.61
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -0.76

Activity Summary

EC50 3 meas. best 7.16

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
EC50 7.16 7.16 69.0 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 6.92 6.92 120.0 1
Beta-3 adrenergic receptor
CHEMBL246
EC50 6.8 6.8 160.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
15686912 10.1016/j.bmcl.2004.12.033 Beta-3 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-1 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Beta-2 adrenergic receptor 2
15686912 10.1016/j.bmcl.2004.12.033 Caco-2 1

Data from ChEMBL 36 via Core Engine