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Compound Detail

CHEMBL3657162

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Cc1c(-c2ccc(O)c(F)c2)n(Cc2ccc(OCCN3CCCCC3)cc2)c2ccc(O)cc12

Basic Information

ChEMBL ID CHEMBL3657162
Phase Preclinical
Structure Type MOL
InChI Key DBIQTOWPZVCCTN-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

474.6
MW (Da)
6.08
ALogP
5
HBA
2
HBD
57.9
PSA (Ų)
0.34
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H31FN2O3
MW 474.58
Aromatic Rings 4
Heavy Atoms 35
NP-Likeness -0.82

Activity Summary

IC50 2 meas. best 8.26

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Estrogen receptor
CHEMBL206
IC50 8.26 8.26 5.5 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine