Compound Detail
CHEMBL3659497
AZD-7451 Phase I
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Phase I
Basic Information
| ChEMBL ID | CHEMBL3659497 |
| Name | AZD-7451 |
| Phase | Phase I |
| Structure Type | MOL |
| InChI Key | AYOOGWWGECJQPI-NSHDSACASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
2
Known Names
1
Indications
3
Mechanisms
Molecular Properties
382.4
MW (Da)
3.03
ALogP
8
HBA
2
HBD
106.4
PSA (Ų)
0.53
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Nerve growth factor receptor Trk-A inhibitor | INHIBITOR | High affinity nerve growth factor receptor | ✓ | ✓ |
| Neurotrophic tyrosine kinase receptor type 2 inhibitor | INHIBITOR | BDNF/NT-3 growth factors receptor | ✓ | ✓ |
| NT-3 growth factor receptor inhibitor | INHIBITOR | NT-3 growth factor receptor | ✓ | ✓ |
Indications
Glioblastoma
Activity Summary
IC50 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 3.0 | nM | 8.52 | Amplified Luminescent Proximity Assay: To measure JAK2 kinase activity, a commer... | - |
Data from ChEMBL 36 via Core Engine