Compound Detail
CHEMBL3662218
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CC1(COc2cc(F)c(C(=O)NS(=O)(=O)C3CC3)cc2C2CC2)CCC(C(F)(F)F)CC1
Basic Information
| ChEMBL ID | CHEMBL3662218 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ADGPBRVGPHOIIO-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
477.5
MW (Da)
5.06
ALogP
4
HBA
1
HBD
72.5
PSA (Ų)
0.56
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha CHEMBL4296 | IC50 | 8.7 | 8.0525 | 2.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | IC50 | = | 2.0 | nM | 8.7 | Radioligand Binding Assay: Radioligand Binding Studies: Saturation experiments. ... | - |
| Sodium channel protein type 9 subunit alpha | IC50 | = | 6.0 | nM | 8.22 | Inhibition of human Nav1.7 alpha subunit expressed in HEK293 cells co-expressing... | 30499663 |
| Sodium channel protein type 9 subunit alpha | IC50 | = | 10.0 | nM | 8.0 | Displacement of [3H]GX-545 from human Nav1.7 alpha subunit expressed in HEK293 c... | 30499663 |
| Sodium channel protein type 9 subunit alpha | IC50 | = | 51.0 | nM | 7.29 | Electrophysiological Assay: Patch voltage clamp electrophysiology allows for the... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30499663 | 10.1021/acs.jmedchem.8b01621 | Sodium channel protein type 9 subunit alpha | 2 |
Data from ChEMBL 36 via Core Engine