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Compound Detail

CHEMBL3677918

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[C-]#[N+]c1ccc2ncc(-c3noc4cc(C(=O)N5CCOCC5)ccc34)n2c1

Basic Information

ChEMBL ID CHEMBL3677918
Phase Preclinical
Structure Type MOL
InChI Key IXNICTFAAMRHNZ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

373.4
MW (Da)
3.17
ALogP
6
HBA
0
HBD
77.2
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H15N5O3
MW 373.37
Aromatic Rings 4
Heavy Atoms 28
NP-Likeness -1.45

Activity Summary

Ki 1 meas. best 6.83

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL251
Ki 6.83 6.83 147.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Adenosine receptor A2a Ki = 147.0 nM 6.83 FRET-Based Binding Assay: Assay protocol: Compounds were evaluated on an in-vitr... -

Data from ChEMBL 36 via Core Engine