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Compound Detail

CHEMBL3680156

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NC1=N[C@@H](c2ccc3ccccc3c2)CO1

Basic Information

ChEMBL ID CHEMBL3680156
Phase Preclinical
Structure Type MOL
InChI Key RJKZMEJDWXVKAC-GFCCVEGCSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

212.2
MW (Da)
2.23
ALogP
3
HBA
1
HBD
47.6
PSA (Ų)
0.79
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H12N2O
MW 212.25
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness 0.15

Activity Summary

Ki 1 meas. best 9.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Trace amine-associated receptor 1
CHEMBL4908
Ki 9.4 9.4 0.4 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Trace amine-associated receptor 1 Ki = 0.4 nM 9.4 Radioligand Binding Assay: Radioligand binding assay using TAAR1. -

Data from ChEMBL 36 via Core Engine