Compound Detail
CHEMBL3681251
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Cc1nc2cc(-n3ncc(C(=O)c4cc5cc(Cl)c(OCC6CC6)cc5[nH]4)c3N)ccc2[nH]1
Basic Information
| ChEMBL ID | CHEMBL3681251 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ONDLQNORJPRVQM-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
460.9
MW (Da)
4.79
ALogP
6
HBA
3
HBD
114.6
PSA (Ų)
0.31
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 7.85 | 7.85 | 14.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.21 | 7.21 | 62.0 | 1 |
| Fibroblast growth factor receptor 3 CHEMBL2742 | IC50 | 7.05 | 7.05 | 90.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 14.0 | nM | 7.85 | Enzyme Inhibition Assay: The FGFR2-inhibiting activity was measured based on the... | - |
| Fibroblast growth factor receptor 1 | IC50 | = | 62.0 | nM | 7.21 | Enzyme Inhibition Assay: The FGFR1-inhibiting activity was measured based on the... | - |
| Fibroblast growth factor receptor 3 | IC50 | = | 90.0 | nM | 7.05 | Enzyme Inhibition Assay: The FGFR3-inhibiting activity was measured based on the... | - |
Data from ChEMBL 36 via Core Engine