Compound Detail
CHEMBL3683162
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COc1cc2c(cc1OC(C)C)[C@H](c1ccc(Cl)cc1)N(c1ccc(N(C)C[C@H]3CC[C@H](N(CC(N)=O)CC(N)=O)CC3)cc1)C(=O)C2
Basic Information
| ChEMBL ID | CHEMBL3683162 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IWXOKKNAMZZBTO-HXNRPOFDSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
676.3
MW (Da)
5.08
ALogP
7
HBA
2
HBD
131.4
PSA (Ų)
0.26
QED
2
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | IC50 | 8.74 | 8.74 | 1.8 | 1 |
| Protein Mdm4 CHEMBL1255126 | IC50 | 5.52 | 5.52 | 3010.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | IC50 | = | 1.8 | nM | 8.74 | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay: The inhibition of p5... | - |
| Protein Mdm4 | IC50 | = | 3010.0 | nM | 5.52 | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay: The inhibition of p5... | - |
Data from ChEMBL 36 via Core Engine