Compound Detail
CHEMBL3687266
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Cc1cc(Cl)ccc1C1c2c(nn(CC(=O)N3CCCC3)c2C(C)C)C(=O)N1c1cc(Cl)ccc1C
Basic Information
| ChEMBL ID | CHEMBL3687266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IVOGMBDXHMRJFP-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
525.5
MW (Da)
6.30
ALogP
4
HBA
0
HBD
58.4
PSA (Ų)
0.39
QED
2
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 CHEMBL5023 | IC50 | 8.7 | 8.7 | 2.0 | 1 |
| Protein Mdm4 CHEMBL1255126 | IC50 | 5.02 | 5.02 | 9457.7 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| E3 ubiquitin-protein ligase Mdm2 | IC50 | = | 2.0 | nM | 8.7 | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay: The inhibition of p5... | - |
| Protein Mdm4 | IC50 | = | 9457.7 | nM | 5.02 | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay: The inhibition of p5... | - |
Data from ChEMBL 36 via Core Engine