Compound Detail
CHEMBL3701256
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C#C[C@@H]1C[C@H](n2nc(C#Cc3cc(OC)cc(OC)c3)c3c(N)ncnc32)CN1C(=O)C=C
Basic Information
| ChEMBL ID | CHEMBL3701256 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QIGKMOZLJKDFKI-SJORKVTESA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
442.5
MW (Da)
1.79
ALogP
8
HBA
1
HBD
108.4
PSA (Ų)
0.48
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 9.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 CHEMBL4142 | IC50 | 9.4 | 9.4 | 0.4 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fibroblast growth factor receptor 2 | IC50 | = | 0.4 | nM | 9.4 | Inhibition Assay: When setting conditions for the measurement of the inhibitory ... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 0.4 | nM | 9.4 | FGFR2 Kinase Activity: When setting conditions for the measurement of the inhibi... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 0.4 | nM | 9.4 | Measurement of Inhibitory Effect on FGFR2 Kinase Activity: When setting conditio... | - |
| Fibroblast growth factor receptor 2 | IC50 | = | 0.4 | nM | 9.4 | Measurement of Inhibitory Effect on FGFR2 Kinase Activity: When setting conditio... | - |
Data from ChEMBL 36 via Core Engine