Compound Detail
CHEMBL3717595
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Cc1cc2c(C(C)C)c(O)c(O)c(/C=N/CCCN3CCOCC3)c2c(O)c1-c1c(C)cc2c(C(C)C)c(O)c(O)c(/C=N/CCCN3CCOCC3)c2c1O
Basic Information
| ChEMBL ID | CHEMBL3717595 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SCUGWLJEBHKBEK-ZXHWGKOWSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
771.0
MW (Da)
7.04
ALogP
12
HBA
6
HBD
171.0
PSA (Ų)
0.05
QED
4
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 6 CHEMBL6144 | IC50 | 5.0 | 5.0 | 10120.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G protein-coupled receptor kinase 6 | IC50 | = | 10120.0 | nM | 5.0 | Inhibition of human recombinant full-length GST-tagged human GRK6 using peptide ... | - |
| G protein-coupled receptor kinase 6 | IC50 | = | 10120.0 | nM | 5.0 | TBD: TBD | - |
Data from ChEMBL 36 via Core Engine