Compound Detail
CHEMBL371944
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Basic Information
| ChEMBL ID | CHEMBL371944 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | TVPKTCDALIWYRU-NSHDSACASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
333.3
MW (Da)
-0.83
ALogP
7
HBA
3
HBD
144.6
PSA (Ų)
0.63
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 4.31
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL2919 | Kd | 4.31 | 4.31 | 49100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Kd | = | 49100.0 | nM | 4.31 | Antagonism on GLUK5 containing kainate induced depolarization of isolated neonat... | 16302825 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16302825 | 10.1021/jm050584l | Glutamate receptor ionotropic, AMPA | 3 |
| 16302825 | 10.1021/jm050584l | Glutamate receptor ionotropic, kainate 1 | 1 |
| 16302825 | 10.1021/jm050584l | Glutamate receptor ionotropic, kainate 2 | 1 |
Data from ChEMBL 36 via Core Engine