Compound Detail
CHEMBL37260
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Basic Information
| ChEMBL ID | CHEMBL37260 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RICKQPKTSOSCOF-HKUYNNGSSA-N |
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
363.4
MW (Da)
2.08
ALogP
3
HBA
3
HBD
99.4
PSA (Ų)
0.66
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Platelet CHEMBL4296519 | IC50 | 6.71 | 6.365 | 194.0 | 4 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 5.24 | 5.24 | 5700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Platelet | IC50 | = | 194.01 | nM | 6.71 | Inhibition of adenosine diphosphate-induced platelet aggregation in pig blood | 18835178 |
| Platelet | IC50 | = | 422.36 | nM | 6.37 | Inhibition of platelet-activating factor-induced platelet aggregation in pig blo... | 18835178 |
| Platelet | IC50 | = | 571.87 | nM | 6.24 | Inhibition of arachidonic acid-induced platelet aggregation in pig blood | 18835178 |
| Platelet | IC50 | = | 719.92 | nM | 6.14 | Inhibition of thrombin-induced platelet aggregation in pig blood | 18835178 |
| Dipeptidyl peptidase 4 | IC50 | = | 5700.0 | nM | 5.24 | Inhibitory concentration against Dipeptidyl peptidase IV (DPP IV) | 9873385 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18835178 | 10.1016/j.bmc.2008.09.019 | Platelet | 4 |
| 9873385 | 10.1016/s0960-894x(98)00259-5 | Dipeptidyl peptidase 4 | 2 |
| 18835178 | 10.1016/j.bmc.2008.09.019 | Rattus norvegicus | 1 |
Data from ChEMBL 36 via Core Engine