Compound Detail
CHEMBL373367
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Basic Information
| ChEMBL ID | CHEMBL373367 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QECWNBHGOWRVDA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
354.5
MW (Da)
5.10
ALogP
6
HBA
0
HBD
44.2
PSA (Ų)
0.51
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.79
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Ribosomal protein S6 kinase beta-2 CHEMBL3111 | IC50 | 4.79 | 4.79 | 16310.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Ribosomal protein S6 kinase beta-2 | IC50 | = | 16310.0 | nM | 4.79 | In vitro inhibition of SR protein kinase 1 by compound dissolved in 100% DMSO us... | 15925511 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Unchecked | 2 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Tyrosine-protein kinase Lck | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Inhibitor of nuclear factor kappa-B kinase subunit beta | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Glycogen synthase kinase-3 beta | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Epidermal growth factor receptor | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Casein kinase I isoform alpha | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Tyrosine-protein kinase transforming protein Abl | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | RAC-alpha serine/threonine-protein kinase | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | No relevant target | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Ribosomal protein S6 kinase (P70S6K) | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Proto-oncogene tyrosine-protein kinase Src | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Ribosomal protein S6 kinase beta-2 | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Hepatocyte growth factor receptor | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Rho-associated protein kinase 2 | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Platelet-derived growth factor receptor beta | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Mitogen-activated protein kinase 3 | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Mast/stem cell growth factor receptor Kit | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Mitogen-activated protein kinase 8 | 1 |
| 15925511 | 10.1016/j.bmcl.2005.04.064 | Insulin receptor | 1 |
Data from ChEMBL 36 via Core Engine