Compound Detail
CHEMBL373429
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Basic Information
| ChEMBL ID | CHEMBL373429 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCZDCKMQSBGXAH-AWEZNQCLSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
429.4
MW (Da)
1.21
ALogP
8
HBA
3
HBD
144.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 7.92
IC50 1 meas. best 4.78
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 CHEMBL2919 | Kd | 7.92 | 7.92 | 12.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.78 | 4.78 | 16600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, kainate 1 | Kd | = | 12.0 | nM | 7.92 | Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-indu... | 17348638 |
| Unchecked | IC50 | = | 16600.0 | nM | 4.78 | Antagonist activity at native AMPA receptor assessed as fDR-VRP reduction of neo... | 17348638 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17348638 | 10.1021/jm061041u | Glutamate receptor ionotropic, kainate 1 | 3 |
| 17348638 | 10.1021/jm061041u | Unchecked | 3 |
| 17348638 | 10.1021/jm061041u | Glutamate receptor ionotropic, kainate 2 | 1 |
| 17348638 | 10.1021/jm061041u | Glutamate receptor 2 | 1 |
| 17348638 | 10.1021/jm061041u | Glutamate NMDA receptor | 1 |
| 17348638 | 10.1021/jm061041u | Metabotropic glutamate receptor 1 | 1 |
| 17348638 | 10.1021/jm061041u | Metabotropic glutamate receptor 5 | 1 |
Data from ChEMBL 36 via Core Engine