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Compound Detail

CHEMBL3739900

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O=C1c2ccccc2C(=O)N1Cc1ccc(CCN2CCN(Cc3ccccc3)CC2)cc1

Basic Information

ChEMBL ID CHEMBL3739900
Phase Preclinical
Structure Type MOL
InChI Key DQNQPTZBYUYYHH-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

439.6
MW (Da)
3.84
ALogP
4
HBA
0
HBD
43.9
PSA (Ų)
0.52
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H29N3O2
MW 439.56
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.91

Activity Summary

IC50 3 meas. best 6.94

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Alpha-1D adrenergic receptor
CHEMBL223
IC50 6.94 6.94 115.5 1
Alpha-1B adrenergic receptor
CHEMBL232
IC50 6.0 6.0 1007.0 1
Alpha-1A adrenergic receptor
CHEMBL229
IC50 5.92 5.92 1200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
26643219 10.1016/j.bmc.2015.11.020 Unchecked 2
26643219 10.1016/j.bmc.2015.11.020 Alpha-1B adrenergic receptor 1
26643219 10.1016/j.bmc.2015.11.020 Alpha-1A adrenergic receptor 1
26643219 10.1016/j.bmc.2015.11.020 Alpha-1D adrenergic receptor 1

Data from ChEMBL 36 via Core Engine