Compound Detail
CHEMBL3753512
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Basic Information
| ChEMBL ID | CHEMBL3753512 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | URHCJSWLNCXUMX-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
324.4
MW (Da)
3.45
ALogP
7
HBA
1
HBD
95.7
PSA (Ų)
0.79
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret CHEMBL2041 | IC50 | 8.7 | 8.275 | 2.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 2.0 | nM | 8.7 | Inhibition of human wild type RET by radiometric assay in presence of [gamma-33P... | 26652860 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | IC50 | = | 14.0 | nM | 7.85 | Inhibition of human Ret V804M mutant by radiometric assay in presence of [gamma-... | 26652860 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26652860 | 10.1021/acs.jmedchem.5b01522 | Proto-oncogene tyrosine-protein kinase receptor Ret | 5 |
| 26652860 | 10.1021/acs.jmedchem.5b01522 | ADMET | 1 |
| 26652860 | 10.1021/acs.jmedchem.5b01522 | BaF3 | 1 |
Data from ChEMBL 36 via Core Engine