Compound Detail
CHEMBL3763822
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Basic Information
| ChEMBL ID | CHEMBL3763822 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOMLCVOFFCJGNU-IAGOWNOFSA-N |
3
Targets
3
Activities
2
Assay Types
5
PK Parameters
5
Publications
0
Known Names
Molecular Properties
361.4
MW (Da)
3.09
ALogP
5
HBA
2
HBD
75.6
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.16
IC50 1 meas. best 8.65
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 CHEMBL3105 | IC50 | 8.65 | 8.65 | 2.2 | 1 |
| PARP 1, 2 and 3 CHEMBL3390820 | EC50 | 8.16 | 8.16 | 6.9 | 1 |
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 6.52 | 6.52 | 305.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| AUC | 36500.0 | ng.hr.mL-1 | Rattus norvegicus |
| CL | 4.0 | mL.min-1.kg-1 | Rattus norvegicus |
| Cmax | 29138.3 | nM | Rattus norvegicus |
| F | 91.0 | % | Rattus norvegicus |
| T1/2 | 2.3 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Poly [ADP-ribose] polymerase 1 | IC50 | = | 2.25 | nM | 8.65 | Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate s... | 26652717 |
| PARP 1, 2 and 3 | EC50 | = | 6.9 | nM | 8.16 | Inhibition of PARP in human LoVo cells assessed as inhibition of poly(ADP)-ribos... | 26652717 |
| NON-PROTEIN TARGET | EC50 | = | 305.0 | nM | 6.52 | Cytotoxicity against BRCA2-deficient human Capan1 cells | 26652717 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26652717 | 10.1021/acs.jmedchem.5b01498 | Rattus norvegicus | 6 |
| 26652717 | 10.1021/acs.jmedchem.5b01498 | PARP 1, 2 and 3 | 1 |
| 26652717 | 10.1021/acs.jmedchem.5b01498 | LoVo | 1 |
| 26652717 | 10.1021/acs.jmedchem.5b01498 | NON-PROTEIN TARGET | 1 |
| 26652717 | 10.1021/acs.jmedchem.5b01498 | Poly [ADP-ribose] polymerase 1 | 1 |
Data from ChEMBL 36 via Core Engine