Compound Detail
CHEMBL376906
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CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)[C@H](NC(=O)CCC2=CC3=Cc4c(C)cc(C)n4[B-](F)(F)[N+]3=C2)[C@H](C)[C@@H](O)[C@]1(C)O
Basic Information
| ChEMBL ID | CHEMBL376906 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VDKFQIUTLIMQLE-QSXLEGLKSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1009.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.82
Kd 1 meas. best 7.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Escherichia coli CHEMBL354 | Kd | 7.52 | 7.52 | 30.0 | 1 |
| Escherichia coli CHEMBL354 | IC50 | 5.82 | 5.82 | 1500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Escherichia coli | Kd | = | 30.0 | nM | 7.52 | Binding affinity to 70S bacterial ribosome isolated from Escherichia coli | 16309904 |
| Escherichia coli | IC50 | = | 1500.0 | nM | 5.82 | Inhibition of ribosome function in a coupled transcription and translational ass... | 16309904 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16309904 | 10.1016/j.bmcl.2005.11.028 | Escherichia coli | 2 |
Data from ChEMBL 36 via Core Engine