Assay Detail
Functional
CHEMBL859064
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Inhibition of ribosome function in a coupled transcription and translational assay using Escherichia coli S30 extracts
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of BODIPY-erythromycin probes for bacterial ribosomes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.50 | 7.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 7.10 |
| CHEMBL373669 | — | — | 1 | 6.80 |
| CHEMBL405286 | — | — | 1 | 6.26 |
| CHEMBL376906 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL373669 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL405286 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL376906 | — | IC50 | = | 1500.0 | nM | 5.82 |