Compound Detail
CHEMBL3769828
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Basic Information
| ChEMBL ID | CHEMBL3769828 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LLJLIQBITIQSJX-UHFFFAOYSA-N |
| Parent Compound | CHEMBL3771383 |
| Active Moiety | CHEMBL3771383 |
3
Targets
8
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
245.2
MW (Da)
2.38
ALogP
2
HBA
1
HBD
35.2
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 8 meas. best 8.14
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2C CHEMBL225 | EC50 | 8.14 | 7.125 | 7.2 | 4 |
| 5-hydroxytryptamine receptor 2A CHEMBL224 | EC50 | 6.44 | 6.44 | 361.0 | 2 |
| 5-hydroxytryptamine receptor 2B CHEMBL1833 | EC50 | 6.34 | 6.34 | 453.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26704965 | 10.1021/acs.jmedchem.5b01153 | 5-hydroxytryptamine receptor 2C | 6 |
| 26704965 | 10.1021/acs.jmedchem.5b01153 | 5-hydroxytryptamine receptor 2B | 6 |
| 26704965 | 10.1021/acs.jmedchem.5b01153 | 5-hydroxytryptamine receptor 2A | 6 |
Data from ChEMBL 36 via Core Engine