Compound Detail
CHEMBL3770630
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Basic Information
| ChEMBL ID | CHEMBL3770630 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DCQUTHFECVSMPM-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
311.4
MW (Da)
1.76
ALogP
8
HBA
1
HBD
96.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | Ki | 8.92 | 8.92 | 1.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Ki | = | 1.2 | nM | 8.92 | Inhibition of recombinant PI3K alpha (unknown origin) using PIP2 as substrate by... | 26741947 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26741947 | 10.1021/acs.jmedchem.5b01483 | Unchecked | 3 |
| 26741947 | 10.1021/acs.jmedchem.5b01483 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
Data from ChEMBL 36 via Core Engine