Compound Detail
CHEMBL3771160
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Basic Information
| ChEMBL ID | CHEMBL3771160 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NHHLRTBGOWCUMQ-WCQYABFASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
282.4
MW (Da)
2.35
ALogP
3
HBA
2
HBD
67.4
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase CHEMBL4349 | IC50 | 4.89 | 4.89 | 12910.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| N-acylethanolamine-hydrolyzing acid amidase | IC50 | = | 12910.0 | nM | 4.89 | Inhibition of human NAAA expressed in HEK293 cells preincubated for 10 mins foll... | 26866968 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26866968 | 10.1016/j.ejmech.2016.01.046 | N-acylethanolamine-hydrolyzing acid amidase | 1 |
Data from ChEMBL 36 via Core Engine