Compound Detail
CHEMBL3780979
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Basic Information
| ChEMBL ID | CHEMBL3780979 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PXCMPGTVPUZXRO-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
198.3
MW (Da)
2.47
ALogP
2
HBA
1
HBD
24.9
PSA (Ų)
0.82
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 6 CHEMBL1275221 | IC50 | 4.0 | 4.0 | 100000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein arginine N-methyltransferase 6 | IC50 | = | 100000.0 | nM | 4.0 | Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells usin... | 26824386 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 26824386 | 10.1021/acs.jmedchem.5b01772 | Protein arginine N-methyltransferase 6 | 1 |
Data from ChEMBL 36 via Core Engine