Assay Detail
Binding
CHEMBL3784078
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal hexa-His tagged human PRMT6 expressed in Sf9 cells using 24 residues of biotin labelled histone4 substrate and tritiated 3H-S-adenosylmethionine by scintillation proximity assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf9 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 6 (CHEMBL1275221) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 4.32 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3780926 | — | — | 1 | 6.64 |
| CHEMBL3780701 | — | — | 1 | 5.68 |
| CHEMBL3780444 | — | — | 1 | 5.30 |
| CHEMBL3763993 | — | — | 1 | 4.62 |
| CHEMBL3781561 | — | — | 1 | 4.34 |
| CHEMBL3780738 | — | — | 1 | 4.16 |
| CHEMBL3779956 | — | — | 1 | 4.14 |
| CHEMBL3780979 | — | — | 1 | 4.00 |
| CHEMBL3781201 | — | — | 1 | 4.00 |
| CHEMBL3402235 | — | — | 1 | 3.98 |
| CHEMBL3780615 | — | — | 1 | 3.90 |
| CHEMBL3781682 | — | — | 1 | 3.87 |
| CHEMBL3781603 | — | — | 1 | 3.84 |
| CHEMBL3781043 | — | — | 1 | 3.77 |
| CHEMBL3781266 | — | — | 1 | 3.44 |
| CHEMBL437 | SULFATHIAZOLE | 4.0 | 1 | 3.37 |
| CHEMBL3781841 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3780926 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL3780701 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL3780444 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL3763993 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL3781561 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL3780738 | — | IC50 | = | 69000.0 | nM | 4.16 |
| CHEMBL3779956 | — | IC50 | = | 72000.0 | nM | 4.14 |
| CHEMBL3780979 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL3781201 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL3402235 | — | IC50 | = | 104000.0 | nM | 3.98 |
| CHEMBL3780615 | — | IC50 | = | 125000.0 | nM | 3.90 |
| CHEMBL3781682 | — | IC50 | = | 136000.0 | nM | 3.87 |
| CHEMBL3781603 | — | IC50 | = | 146000.0 | nM | 3.84 |
| CHEMBL3781043 | — | IC50 | = | 170000.0 | nM | 3.77 |
| CHEMBL3781266 | — | IC50 | = | 360000.0 | nM | 3.44 |
| CHEMBL437 | SULFATHIAZOLE | IC50 | = | 430000.0 | nM | 3.37 |
| CHEMBL3781841 | — | IC50 | > | 200000.0 | nM | - |