Compound Detail
CHEMBL437
SULFATHIAZOLE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL437 |
| Name | SULFATHIAZOLE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | JNMRHUJNCSQMMB-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
8
Targets
15
Activities
2
Assay Types
0
PK Parameters
20
Publications
13
Known Names
1
Indications
1
Mechanisms
Molecular Properties
255.3
MW (Da)
1.53
ALogP
5
HBA
2
HBD
85.1
PSA (Ų)
0.81
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1945 |
| Availability | Withdrawn |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial dihydropteroate synthase inhibitor | INHIBITOR | Dihydropteroate synthase | ✓ | ✓ |
Indications
Bacterial Infections
ATC Classification
D06BA02
sulfathiazole
Level 1: DERMATOLOGICALS
Level 2: ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
J01EB07
sulfathiazole
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
Drug Warnings
Withdrawn
nephrotoxicity
renal complications, rash, fever, blood dyscrasias, and liver damage
Withdrawn
hepatotoxicity
renal complications, rash, fever, blood dyscrasias, and liver damage
Withdrawn
dermatological toxicity
renal complications, rash, fever, blood dyscrasias, and liver damage
Withdrawn
General Warning
crystalluria
Withdrawn
General Warning
serious side effects
Withdrawn
hematological toxicity
renal complications, rash, fever, blood dyscrasias, and liver damage
Withdrawn
hepatotoxicity
renal complications, rash, fever, blood dyscrasias, and liver damage
Activity Summary
IC50 13 meas. best 5.6
Ki 2 meas. best 4.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dihydropteroate synthase CHEMBL4032 | IC50 | 5.6 | 5.6 | 2500.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.12 | 4.7433 | 7550.0 | 3 |
| Escherichia coli CHEMBL354 | IC50 | 5.11 | 5.11 | 7800.0 | 1 |
| Transcriptional activator protein LasR CHEMBL1075207 | IC50 | 5.05 | 5.05 | 9000.0 | 2 |
| Unchecked CHEMBL612545 | Ki | 4.85 | 4.85 | 14000.0 | 1 |
| No relevant target CHEMBL2362975 | IC50 | 4.28 | 4.28 | 52095.0 | 1 |
| Endothelin-1 receptor CHEMBL252 | IC50 | 4.16 | 4.16 | 69000.0 | 1 |
| Endothelin-1 receptor CHEMBL4566 | IC50 | 4.16 | 4.16 | 69000.0 | 1 |
| Protein arginine N-methyltransferase 6 CHEMBL1275221 | IC50 | 3.37 | 3.37 | 430000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
Literature References
Data from ChEMBL 36 via Core Engine