Assay Detail
Binding
CHEMBL664446
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In vitro inhibition of dihydropteroate synthase from Escherichia coli.
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.10 | 5.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL442357 | — | — | 1 | 5.85 |
| CHEMBL55866 | — | — | 1 | 5.80 |
| CHEMBL291953 | — | — | 1 | 5.60 |
| CHEMBL437 | SULFATHIAZOLE | 4.0 | 1 | 5.60 |
| CHEMBL56190 | — | — | 1 | 5.55 |
| CHEMBL58777 | — | — | 1 | 5.43 |
| CHEMBL59151 | — | — | 1 | 5.38 |
| CHEMBL443 | SULFAMETHOXAZOLE | 4.0 | 1 | 5.33 |
| CHEMBL291324 | — | — | 1 | 5.24 |
| CHEMBL56233 | — | — | 1 | 5.23 |
| CHEMBL299333 | — | — | 1 | 5.11 |
| CHEMBL291509 | — | — | 1 | 5.05 |
| CHEMBL55865 | — | — | 1 | 4.96 |
| CHEMBL55589 | — | — | 1 | 4.89 |
| CHEMBL56063 | — | — | 1 | 4.75 |
| CHEMBL53450 | — | — | 1 | 4.68 |
| CHEMBL55911 | — | — | 1 | 4.46 |
| CHEMBL56302 | — | — | 1 | 4.00 |
| CHEMBL293797 | — | — | 1 | 4.00 |
| CHEMBL55165 | — | — | 1 | - |
| CHEMBL301649 | — | — | 1 | - |
| CHEMBL56260 | — | — | 1 | - |
| CHEMBL57846 | — | — | 1 | - |
| CHEMBL56748 | — | — | 1 | - |
| CHEMBL55373 | — | — | 1 | - |
| CHEMBL55588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL442357 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL55866 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL291953 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL437 | SULFATHIAZOLE | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL56190 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL58777 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL59151 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL443 | SULFAMETHOXAZOLE | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL291324 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL56233 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL299333 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL291509 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL55865 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL55589 | — | IC50 | = | 12900.0 | nM | 4.89 |
| CHEMBL56063 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL53450 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL55911 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL56302 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL293797 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL55165 | — | IC50 | = | 200000.0 | nM | - |
| CHEMBL301649 | — | IC50 | = | 197000.0 | nM | - |
| CHEMBL56260 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL57846 | — | IC50 | = | 290000.0 | nM | - |
| CHEMBL56748 | — | IC50 | = | 300000.0 | nM | - |
| CHEMBL55373 | — | IC50 | = | 208000.0 | nM | - |
| CHEMBL55588 | — | IC50 | = | 110000.0 | nM | - |