Assay Detail
Binding
CHEMBL678229
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Inhibitory concentration against Endothelin A receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Selective optimization of side activities: another way for drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.70 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL267458 | BMS-182874 | — | 1 | 6.82 |
| CHEMBL453 | SULFISOXAZOLE | 4.0 | 1 | 6.11 |
| CHEMBL437 | SULFATHIAZOLE | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL267458 | BMS-182874 | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL453 | SULFISOXAZOLE | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL437 | SULFATHIAZOLE | IC50 | = | 69000.0 | nM | 4.16 |