Assay Detail
Functional
CHEMBL3285745
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Antibacterial activity against sensitive Escherichia coli ATCC 10536 assessed as reduction in growth
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Escherichia coli |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Antifolate studies. Activities of 40 potential antimalarial compounds against sensitive and chlorguanide triazine resistant strains of folate-requiring bacteria and Escherichia coli.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 4.98 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1877296 | — | — | 1 | 6.40 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.40 |
| CHEMBL129788 | — | — | 1 | 5.77 |
| CHEMBL3272425 | — | — | 1 | 5.70 |
| CHEMBL3272426 | — | — | 1 | 5.32 |
| CHEMBL1213592 | CLOCIGUANIL | 2.0 | 1 | 5.16 |
| CHEMBL437 | SULFATHIAZOLE | 4.0 | 1 | 5.11 |
| CHEMBL568202 | — | — | 1 | 5.09 |
| CHEMBL285373 | — | — | 1 | 5.00 |
| CHEMBL31695 | — | — | 1 | 4.96 |
| CHEMBL439 | SULFADIAZINE | 4.0 | 1 | 4.92 |
| CHEMBL1525826 | SULFALENE | 3.0 | 1 | 4.87 |
| CHEMBL2009682 | — | — | 1 | 4.77 |
| CHEMBL3249753 | — | — | 1 | 4.54 |
| CHEMBL414017 | — | — | 1 | 4.48 |
| CHEMBL56129 | — | — | 1 | 4.35 |
| CHEMBL3272430 | — | — | 1 | 4.30 |
| CHEMBL3272432 | — | — | 1 | 4.29 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 4.12 |
| CHEMBL1939337 | — | — | 1 | 4.07 |
| CHEMBL1999063 | MENOCTONE | 2.0 | 1 | - |
| CHEMBL295830 | CYCLOLEUCINE | — | 1 | - |
| CHEMBL1979892 | — | — | 1 | - |
| CHEMBL3272431 | — | — | 1 | - |
| CHEMBL170 | QUININE | 4.0 | 1 | - |
| CHEMBL1995683 | — | — | 1 | - |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | - |
| CHEMBL3182002 | — | — | 1 | - |
| CHEMBL446918 | CLOPIDOL | 2.0 | 1 | - |
| CHEMBL1043 | DAPSONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1877296 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL129788 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL3272425 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL3272426 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL1213592 | CLOCIGUANIL | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL437 | SULFATHIAZOLE | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL568202 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL285373 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL31695 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL439 | SULFADIAZINE | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL1525826 | SULFALENE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL2009682 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL3249753 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL414017 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL56129 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL3272430 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL3272432 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL1939337 | — | IC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL530718 | — | IC50 | = | 1900000.0 | nM | - |
| CHEMBL268584 | — | IC50 | < | 200.0 | nM | - |
| CHEMBL1992508 | — | IC50 | = | 209000.0 | nM | - |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 143000.0 | nM | - |
| CHEMBL3272429 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL1043 | DAPSONE | IC50 | = | 137000.0 | nM | - |
| CHEMBL446918 | CLOPIDOL | IC50 | > | 5200000.0 | nM | - |
| CHEMBL3182002 | — | IC50 | = | 262000.0 | nM | - |
| CHEMBL747 | CYCLOGUANIL | IC50 | > | 3470000.0 | nM | - |
| CHEMBL1995683 | — | IC50 | = | 182000.0 | nM | - |
| CHEMBL170 | QUININE | IC50 | = | 1300000.0 | nM | - |
| CHEMBL3272431 | — | IC50 | > | 4480000.0 | nM | - |
| CHEMBL1979892 | — | IC50 | > | 5000000.0 | nM | - |
| CHEMBL295830 | CYCLOLEUCINE | IC50 | > | 7700000.0 | nM | - |
| CHEMBL1999063 | MENOCTONE | IC50 | > | 2700000.0 | nM | - |