Compound Detail
CHEMBL379891
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Basic Information
| ChEMBL ID | CHEMBL379891 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WHNRNSBFFQOJPP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
383.9
MW (Da)
6.13
ALogP
5
HBA
2
HBD
62.6
PSA (Ų)
0.45
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate NMDA receptor CHEMBL1907608 | Ki | 7.64 | 7.64 | 23.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate NMDA receptor | Ki | = | 23.0 | nM | 7.64 | Inhibition of [3H]glycine binding to NMDA receptor in rat brain membranes | 16451052 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16451052 | 10.1021/jm0503493 | Glutamate NMDA receptor | 1 |
| 16451052 | 10.1021/jm0503493 | L cells | 1 |
Data from ChEMBL 36 via Core Engine