Compound Detail
CHEMBL383319
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CCCn1c(=O)c2nc(-c3cc(OCC(=O)c4ccc(C(=O)OCC)cc4)nn3C)[nH]c2n(CCC)c1=O
Basic Information
| ChEMBL ID | CHEMBL383319 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BWSHNHONBPSTAX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
522.6
MW (Da)
2.55
ALogP
11
HBA
1
HBD
143.1
PSA (Ų)
0.23
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 7.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adenosine receptor A2a CHEMBL251 | Ki | 7.49 | 7.49 | 32.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adenosine receptor A2a | Ki | = | 32.36 | nM | 7.49 | Binding affinity to recombinant human adenosine A2A receptor | 16392813 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16392813 | 10.1021/jm0506221 | Adenosine receptor A2b | 1 |
| 16392813 | 10.1021/jm0506221 | Adenosine receptor A2a | 1 |
Data from ChEMBL 36 via Core Engine