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Compound Detail

CHEMBL384120

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Oc1ccc([C@@H]2c3c(O)cc(O)cc3[C@@H]3c4c(cc(O)cc4[C@H]2[C@@H]2c4cc(O)cc5c4[C@@H](c4cc(O)cc(O)c4[C@H]2c2ccc(O)cc2)[C@H](c2ccc(O)cc2)O5)O[C@H]3c2ccc(O)cc2)cc1

Basic Information

ChEMBL ID CHEMBL384120
Phase Preclinical
Structure Type MOL
InChI Key YQQUILZPDYJDQJ-KGDQSQJYSA-N
6
Targets
9
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

906.9
MW (Da)
10.43
ALogP
12
HBA
10
HBD
220.8
PSA (Ų)
0.08
QED
4
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C56H42O12
MW 906.94
Aromatic Rings 8
Heavy Atoms 68
NP-Likeness 0.80

Activity Summary

IC50 9 meas. best 6.6

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Angiotensin-converting enzyme 2
CHEMBL3736
IC50 6.6 6.6 250.0 1
Human alphaherpesvirus 1
CHEMBL377
IC50 5.55 5.55 2800.0 1
Unchecked
CHEMBL612545
IC50 5.54 5.3 2900.0 2
Human alphaherpesvirus 2
CHEMBL370
IC50 5.19 5.19 6400.0 1
Influenza A virus
CHEMBL613740
IC50 5.19 5.19 6400.0 1
Aldo-keto reductase family 1 member B1
CHEMBL2622
IC50 4.16 4.16 69000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22209731 10.1016/j.bmc.2011.11.067 Mus musculus 8
31534650 10.1039/C9MD00146H Unchecked 3
10571175 10.1016/s0960-894x(99)00520-x SAOS-2 2
20735051 10.1021/np1002675 HFF 2
25405587 10.1021/np500433z Unchecked 2
22209731 10.1016/j.bmc.2011.11.067 Acidic alpha-glucosidase 1
36657039 10.1021/acs.jnatprod.2c01030 Angiotensin-converting enzyme 2 1
36657039 10.1021/acs.jnatprod.2c01030 Programmed cell death protein 1/Programmed cell death 1 ligand 1 1
32652408 10.1016/j.ejmech.2020.112541 Human alphaherpesvirus 2 1
32652408 10.1016/j.ejmech.2020.112541 Human alphaherpesvirus 1 1
32652408 10.1016/j.ejmech.2020.112541 Influenza A virus 1
25405587 10.1021/np500433z NON-PROTEIN TARGET 1
22209731 10.1016/j.bmc.2011.11.067 Aldo-keto reductase family 1 member B1 1
22209731 10.1016/j.bmc.2011.11.067 Sucrase-isomaltase, intestinal 1
10571175 10.1016/s0960-894x(99)00520-x KB 1
22209731 10.1016/j.bmc.2011.11.067 Intestine 1
10571175 10.1016/s0960-894x(99)00520-x HCT-8 1
10571175 10.1016/s0960-894x(99)00520-x 1A9 1
10571175 10.1016/s0960-894x(99)00520-x MCF7 1
10571175 10.1016/s0960-894x(99)00520-x CAKI-1 1

Data from ChEMBL 36 via Core Engine