Compound Detail
CHEMBL387304
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Basic Information
| ChEMBL ID | CHEMBL387304 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VOLVHVOAIIZMJZ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
354.5
MW (Da)
4.88
ALogP
4
HBA
1
HBD
64.3
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 3 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor 4 CHEMBL3190 | EC50 | 6.0 | 6.0 | 1009.0 | 1 |
| Glutamate receptor 2 CHEMBL4016 | EC50 | 5.94 | 5.775 | 1137.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor 4 | EC50 | = | 1009.0 | nM | 6.0 | Activity against human GLUR4 flip expressed in HEK293 cells assessed as glutamat... | 16879964 |
| Glutamate receptor 2 | EC50 | = | 1137.0 | nM | 5.94 | Activity against human GLUR2 flip expressed in HEK293 cells assessed as glutamat... | 16879964 |
| Glutamate receptor 2 | EC50 | = | 2433.0 | nM | 5.61 | Activity against human GLUR2 flop expressed in HEK293 cells assessed as glutamat... | 16879964 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16879964 | 10.1016/j.bmcl.2006.07.035 | Glutamate receptor 4 | 2 |
| 16879964 | 10.1016/j.bmcl.2006.07.035 | Glutamate receptor 2 | 2 |
Data from ChEMBL 36 via Core Engine