Compound Detail
CHEMBL387462
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Basic Information
| ChEMBL ID | CHEMBL387462 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | METFGSCNIQTFJC-SVRRBLITSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
228.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.89
Ki 2 meas. best 6.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase CHEMBL3202 | IC50 | 6.89 | 6.89 | 130.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | Ki | 6.46 | 6.46 | 350.0 | 1 |
| Prolyl endopeptidase CHEMBL3202 | Ki | 5.57 | 5.57 | 2705.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 5.54 | 5.54 | 2900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase | IC50 | = | 130.0 | nM | 6.89 | Inhibition of human PREP using Z-Gly-Pro-AMC as substrate preincubated for 10 mi... | 23594271 |
| Prolyl endopeptidase FAP | Ki | = | 350.0 | nM | 6.46 | Inhibitory constant against FAP | 17174090 |
| Prolyl endopeptidase | Ki | = | 2705.0 | nM | 5.57 | Inhibitory constant against POP | 17174090 |
| Prolyl endopeptidase FAP | IC50 | = | 2900.0 | nM | 5.54 | Inhibition of human FAP using Z-Gly-Pro-AMC as substrate preincubated for 10 min... | 23594271 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Dipeptidyl peptidase 4 | 1 |
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Prolyl endopeptidase | 1 |
| 17174090 | 10.1016/j.bmcl.2006.11.072 | Prolyl endopeptidase FAP | 1 |
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase | 1 |
| 23594271 | 10.1021/jm400351a | Prolyl endopeptidase FAP | 1 |
| 23594271 | 10.1021/jm400351a | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine